Statistics
- Genetic factors account for up to 30% of inter-individual variability in drug metabolism and response
- Severe drug reactions may account for about 5% of all hospitalizations and >100,000 annual deaths in the US
- 59% of the 27 most commonly used drugs are metabolized by at least one enzyme with a variant allele associated with decreased function
- Severe adverse drug effects ranks among the eight most frequent causes of death
- 1 € spent for initial treatment = an additional 1 € spent to treat side effects
