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Anne T. Nies PD Dr.

Head Membrane Transport Proteins
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen
Auerbachstrasse 112
70376 Stuttgart
Germany

Phone: +49 (0) 711 - 8101 3729
Fax: +49 (0) 711 - 859 295
e-mail: anne.nies@ikp-stuttgart.de

Education and Scientific Career

  • 1984 - 1990
    Studies of Biology, University of Düsseldorf, Germany
  • 1990
    Diploma in Biology, University of Düsseldorf
  • 1990 - 1993
    PhD thesis in Biology, University of Düsseldorf
  • 1993
    Dr. rer. nat. (Ph.D.) in Biology, University of Düsseldorf, on transport and metabolism of urate in the hepatopancreas of the lobster
  • 1994 - 1996
    Postdoctoral Research Fellow of the Deutsche Forschungs­gemeinschaft at Tufts University, Department of Physiology (Boston, MA, USA), on the biochemistry und molecular biology of P-glycoprotein and other hepatic transport systems
  • 1996 - 2007
    Senior Research Scientist at the German Cancer Research Center, Division of Tumor Biochemistry, Heidelberg, Germany Research area: Molecular cell biology of ATP-dependent efflux pumps and uptake transporters in the plasma membrane
  • 2004
    Habilitation and venia legendi in Biochemistry, University of Heidelberg Medical School since
  • 2007
    Senior Group Leader, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
  • 2008
    Venia legendi in Biochemical Pharmacology, University of Tübingen Medical School, Germany

Main Research Projects

Molecular cell biology of drug transporters
Functional characterization of drug transporters
Pharmacogenomics of drug transporters

Selected References

  • Emami Riedmaier A, Nies AT, Schaeffeler E, Schwab M (2012) Organic anion transporters and their implications in pharmacotherapy. Pharmacol Rev, 2012 Jul;64(3):421-49
  • Nies AT, Hofmann U, Resch C, Schaeffeler E, Rius M, Schwab M (2011) Proton pump inhibitors inhibit metformin uptake by organic cation uptake transporters (OCTs). PLoS ONE 6, e22163
  • Damme K, Nies AT, Schaeffeler E, Schwab M (2011) Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics. Drug Metab Rev 43, 499-523.
  • Nies AT, Koepsell H, Damme K, Schwab M (2011) Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. Handb Exp Pharmacol. 201, 105-167
  • Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E (2009) Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SCL22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 50, 1227-1240.
  • Nies AT, Herrmann E, Brom M, Keppler D (2008) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch Pharmacol 376, 449-461.
  • Nies AT, Schwab M, Keppler D (2008) Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs. Expert Opin Drug Metab Toxicol 4, 545-568.
  • Bronger H, König J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D, Nies AT (2005) ABCC drug efflux pumps and OATP uptake transporters in human gliomas and the blood-tumor barrier. Cancer Res 65, 11419-11428.
  • Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, König J (2002) A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J Biol Chem 277, 43058-43063.